| abstract |
The present invention relates to compounds of formula I wherein R1 and R2 are independently hydrogen, A, OH, OA or halogen, or R1 and R2 together are C3-C5 alkylene, -O-CH2-CH2-, -CH2-O-. R 2 and R 4 are independently hydrogen or A, X is R 5, R 6 or R 7, each of which is R 8 -substituted, R 5 is -CH 2 -O-CH 2 -O- or -O-CH 2 -CH 2 -O-; straight or branched chain alkylene of 1 to 10 carbon atoms in which one or two CH 2 groups may be replaced by -CH = CH, oxygen, sulfur or SO, R 6 is C 5 -C 12 cycloalkyl or cycloalkylalkylene, R 7 is phenyl or phenylmethyl R 8 is COOH, COOA, CONH 2, CONHA, CON (A) 2 or CN, A is C 1 -C 6 alkyl, Hal is fluorine, chlorine, bromine or iodine, and their physiologically acceptable salts and solvates are used. k for the preparation of a medicament. HE |