http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0302606-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44e0905262f429c7590b40df8448c0c5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-00 |
| filingDate | 2001-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44a991c2e916fa5449774e918e2d5a06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b19ce069f15da12083f5b17fd14e79ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_512445322b748c332e7d134cddb492d1 |
| publicationDate | 2004-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0302606-A2 |
| titleOfInvention | Substituted 3,4-dihydro-pyrimido [1,2-a] pyrimidines and 3,4-dihydro-pyrazino [1,2-a] pyrimidines, process for their preparation and pharmaceutical compositions containing them |
| abstract | The present invention relates to substituted 3,4-dihydropyrimido [1,2-a] primidine derivatives and 3,4-dihydropyrazino [1,2-a] pyrimidine derivatives of the general formula (I), for the preparation of these compounds. material library, pharmaceutical compositions containing the above compounds, use of the above compounds in the manufacture of a medicament for the treatment of pain, urinary incontinence, itching, Tinnitus aurium and / or diarrhea, and pharmaceutical compositions containing the above compounds. In the formula (I), Y is CR 8 and Z is N; or Y is N and Z is CR 9; R1 and R2 are independently hydrogen, OR10, SH, SRI0, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylheteroaryl, which may also be substituted; R3 and R4 are independently hydrogen; or unsubstituted or substituted alkyl, cycloalkyl; aryl, heteroaryl, alkyl-aryl or alkyl-heteroaryl; or one of R 1 or R 2 with one of R 3 or R 4 forms W; R5 is unsubstituted or substituted acyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylheteroaryl or C (= O) R11, CO2H or CO2R12; R 6, R 7, R 8 and R 9 are independently hydrogen, fluoro, chloro, bromo, iodo, cyano, amino, NH (C 1-6 alkyl), N (C 1-6 alkyl) 2, NH (( C 1-6 -alkyl) -aryl), N - ((C 1-6 -alkyl) -aryl) 2, NH-aryl, N (aryl) 2, NHR 13, NO 2, OH, SH, O- (Cl-8- alkyl) alkyl, S (O) p-C 1-8 alkyl, O-aryl, S (O) q-aryl, O- (C 1-6 alkyl) -aryl, S (O) r - (Cl- 6-alkyl) -aryl or CO 2 H, C (O) R 14, or optionally substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, or trifluoromethyl, or R 6 and R 7 together form Q; R10 is optionally substituted alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl; R11 is NH2, NH (C1-6 alkyl), N- (C1-6 alkyl) 2 NH ((C1-8 alkyl) aryl), (C1-6 alkyl) aryl) 2, NH aryl , N (aryl) 2, C 1-8 alkyl; or optionally substituted cycloalkyl, aryl, heteroaryl, alkylaryl or alkylheteroaryl; R12 is optionally substituted alkyl, cycloalkyl or alkylaryl; R 13 is C (= O) CH 3, C (= O) phenyl, C (= O) O-t-butyl (t-BOC), or any other conventional amino protecting group; R 14 is hydrogen, NH 2, NH (C 1-6 alkyl), N (C 1-6 alkyl) 2, NH ((C 1-6 alkyl) aryl), N - ((C 1-6 alkyl) aryl) 2, NH-aryl, N (aryl) 2, C1-8-alkyl; or optionally substituted cycloalkyl, alkylaryl, alkoxy, cycloalkoxy, aryloxy or O- (C 1-6 alkyl) aryl, R 15, R 16, R 17 and R 18 independently of one another are hydrogen, fluoro, chloro , bromine, iodine, hydroxy, cyano, alkyl or carboxyl, and R19, R20, R21 and R22 are |
| priorityDate | 2000-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 211.