| abstract |
The present invention relates, on the one hand, to substituted thioacetamides of formulas (IA), (I, II-A and II) .The present invention, on the other hand, relates to their pharmaceutical compositions and to the use of the compounds in the treatment of diseases. Ar1 and Ar2 are independently aryl or heteroaryl, Y is alkylene, -C (R1) (R2) -, wherein R1 and R2 are independently hydrogen or alkyl, arylene, heteroarylene, cycloalkylene, heterocyclylene, - O -, -N (R8) -, -S (O) Y, -CR8A = CR8B-, -CH = CH-CH (R8) - -CH (R8) -CH = CH- or-C <C-; R3 and R4 are independently selected from the group consisting of hydrogen, alkyl, -OH, or -CH (R6) -CONR8AR8B, or R3 and R4, taken together with an nitrogen atom, form a heterocyclyl ring, R6 is hydrogen, alkyl, or an alpha-amino acid residue. a, R8, R8A and R8B are hydrogen, alkyl or aryl, 0, 1, 2 or 3, n is 0, 1, 2 or 3, p is 1, 2, 3 or 4, y is 0, 1 or 2 . HE |