| abstract |
The present invention relates to compounds of formula (I). R1 and R2 are independently at each occurrence -H, -halogen, -C1-6alkyl, -OR ', -SR', -NR'R <, -SOR ', -SO2R', -COOR ', - OCOR', - OCONR'R <, -OSO2R ', -OSO2NR'R <; -NR'SO2R <, -NR'COR <, -SO2NR'R <, -SO2 (CH2) 1-3CONR'R <, -CONR'R <, cyano, haloalkyl or nitro; R 'and R <are each independently hydrogen, C 1-6 alkyl, substituted C 1-6 alkyl, aryl, heterocyclyl, heteroaryl, aryl (C 1-3 alkyl), heteroaryl (1-3); C 1-4 alkyl, heterocyclyl-C 1-3 alkyl, cycloalkylalkyl, or cycloalkyl; or R 'and R <together with the nitrogen atom to which they are attached form a 5-7 membered ring optionally containing an additional N, O or S (O) 0-2 heteroatom; R3 is independently at each occurrence C 1-6 alkyl, C 1-6 alkenyl, C 1-6 alkynyl, or cycloalkyl; X, Y and Z are each one of -S-, -O-, or N-R 4 and the other is -CH 2 -; R 4 is hydrogen, C 1-6 alkyl, haloalkyl, arylC 1-6 alkyl, heteroaryl (C 1-6 alkyl), - (C 1-6) -CR'R'R ' , -COOR ', -SO2R', -C (O) R ', -SO2- (CH2) 0-3 -NR'R <, -CONR'R <or -PO (OR') 2, wherein R 'and R <is as defined above; p is 1-3; m is 0-3; n is 1-6. The compounds of the present invention are useful in the treatment of diseases associated with smooth muscle disorders. SHE |