| abstract |
In the general formula (1) of the present invention, A, C, and D are independently N or C-R9, wherein R9 is a hydrogen atom, a halogen atom, a lower alkyl group, an alkenyl group, an alkynyl group, an amino group, CN, SH CHO, COOH, CH2OH, a vinyl halide, or hydroxyl, B is nitrogen or carbon, Z is O, CH2 or S, R2 'and R3' are independently hydrogen, hydroxyl or halogen, R1, R2, R3, R4 and R5 are independently hydrogen, halogen, CN, CH2OH, lower alkyl, vinyl or acetylene, with the proviso that when R2 is hydroxy, R2 'is other than halogen, and when R3 is hydroxyl, R3' is other than halogen, R6 is hydrogen, hydroxyl, -CH2OH, -CH2CO (OH) 2, O -amino acid, O-retinoic acid, O-cholesterol, O-cholic acid, O-coumaric acid, O-salicylic acid, O-succinic acid , O-bile acid, O-lipid, OP (O) - (O-CH2-CH2-S-CO-CH3) 2, O-steroid, O-monophosphate derivative, O-diphosphate derivative or O-triphosphate derivative, R7 is hydrogen, alkyl, CH3COO-, CH3COO-phenyl-CH2-O-CO-, phenyl, - (CH2) n-COOH, coumaric acid, salicylic acid, dithiosuccinoyl derivative, reductase-cleavable group, phosphonoformic acid or phosphoramidate group, R8 is hydrogen, lower phenyl, lower alkyl, -phenyl-CH2-O-CO-, phenyl or - (CH2) n-COOH, or R7 and R8 together are a cyclic structure or an amino acid, provided that i) when R1, R2, R3, R4, R5, R7 and R8 is hydrogen, and R2 'and R3' are hydroxyl, then R6 is other than hydroxyl, ii) when R1, R2, R3, R4, R5 and R8 are hydrogen and R2 ', R3' and R6 are hydroxyl, then R7 is other than hydrogen. The compounds of the invention are useful in the treatment of viral infections. SHE |