| abstract |
The present invention relates to cell proliferative compounds of formula (I), pharmaceutically acceptable salts thereof, and esters which can be hydrolysed in vivo, wherein p is 0-4; R 1 is halogen or nitro, cyano, hydroxy, amino, carboxyl, carbamoyl, mercapto, alkyl, alkenyl or alkynyl; q is 0-2; wherein p and q are 1-5; R2 is sulfamoyl or B-E-; R3 is hydrogen or alkyl, alkenyl, alkynyl, or cycloalkyl, and may be optionally substituted on carbon by one or more M substituents on R3; and R4 is alkyl, alkenyl, alkynyl, cycloalkyl or heterocyclyl, and where R4 is optionally substituted with one or more M; and the -NH- group in the heterocyclyl group may be optionally substituted with Z; or R 3 and R 4 together with the nitrogen atom to which they are attached form a heterocyclic ring moiety to which one or more M or Q may be attached. The invention also relates to pharmaceutical compositions containing the compounds. SHE |