| abstract |
The present invention relates to oxazolidinone derivatives of formula (1) and their pharmaceutically acceptable salts having a broad spectrum inhibitory effect on bacteria. Another object of the present invention is a process for the preparation of oxazolidinone derivatives of formula (1) or pharmaceutically acceptable salts thereof. The present invention further provides pharmaceutical compositions having a therapeutic agent of the general formula (1) oxazolidinone derivative or a pharmaceutically acceptable salt thereof. In the general formula (1), R1 is hydrogen, fluorine, chlorine or CF3; R2 is a group of formula (a) or (b) wherein R3 is an amino group or a substituted piperazinyl group, or a 5- or 6-membered heterocyclic group containing one or more nitrogen or oxygen atoms or both. SHE |