| abstract |
The present invention relates to compounds of formula IA or IB, wherein R 1 is a), b), c) or d) or -NH (CH 2) 2 OH, -NR 3 C (O) CH 3 or -NR 3 C (O) cyclopropyl group; R2 is methyl or chloro; R3 is hydrogen or methyl; R is hydrogen or - (CH 2) 2 OH and n is 1 or 2] and are pharmaceutically acceptable acid addition salts thereof. The compounds of the present invention have good affinity for the NK-1 receptor and are therefore useful in the treatment or prevention of these receptor-related diseases. The invention also relates to the preparation and use of the compounds. SHE |