| abstract |
The present invention relates to quinazoline derivatives of the formula I, their preparation, use and pharmaceutical compositions containing them, wherein R2 and R3 are hydrogen or alkyl, m is 0, 1, 2 or 3, R1 is halogen, trifluoromethyl, cyano. , isocyano, nitro, hydroxyl, mercapto, amino, formyl, carboxyl, carbamoyl, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio , alkylsulfinyl, alkylsulfonyl, alkanoyl, alkanoyloxy, sulfamoyl or sulfonylamino, or substituted derivatives thereof, or the group (R1) m may be alkylenedioxy; S, SO, SO2, N (R11), CO, CH (O11), CON (R11), N (R11) CO, SO2N (R11), N (R11) SO2, OC (R11) 2, SC (R11) 2 or N (R 11) C (R 11) 2 in which R 11 represents hydrogen or C 1-6 alkyl; Q1 is aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, and Q2 is of formula (Ia). aryl. HE |