| abstract |
The present invention relates to 2-aminothiazoline derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen or alkyl and R 2 is alkyl, -alk-NH 2, -CH 2 -R 3, -CH 2 -S-R 4 or nitro-substituted phenyl. or -NH-C (= NH) CH3, or R1 is alkyl and R2 is hydrogen, R3 is -cycloalkyl, pyridyl, pyridyl-N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl, phenyl or phenyl substituted with nitro, hydroxy or carboxyl, R4 is pyridyl or pyridyl N-oxide, alk is alkylene. The present invention also relates to the preparation of such compounds, pharmaceutical compositions containing them and their use as NO synthase inhibitors. HE |