| abstract |
The present invention relates to compounds of formula I wherein Ar is unsubstituted or mono-R3-substituted phenyl or naphthyl; R1 and R2 are independently H, A, OA, Hal or CF3; R3 is A, OA, Hal or CF3; A is alkyl having 1, 2, 3, 4, 5 or 5 carbon atoms; and Hal represents fluorine, chlorine, bromine or iodine, and salts and solvates thereof as NHE-3 inhibitors. The invention relates to pharmaceutical compositions containing them and to their use. SHE |