| abstract |
The present invention relates to a process for the preparation of a spirinamine-1,4-bridge-containing ketinocidin compound by 1,4-hydroxylating a 10-hydroxy, 18-protected hydroxy, di-6,8-ene containing a 1-labile group. With 5-fused ring compound, wherein the C-18 protecting group is removed prior to spiroaminobutene. The process of the present invention is advantageously used for the preparation of the ecteinascidin compounds of formula (XIV). HE |