| abstract |
The present invention relates to a group of N-substituted diazabicyclic compounds of formula (I) and to the regulation of the neurotransmitter selectivity of these compounds and of pharmaceutical compositions containing these compounds in a mammal. In the formula (I), A is a covalent bond, -CH 2, -CH 2 CH 2 - or -CH 2 CH 2 CH 2 -; B is -CH 2 - or -CH 2 CH 2 - with the proviso that when A is -CH 2 CH 2 CH 2 - then B is -CH 2 -; Y is a covalent bond, -CH 2 or -CH 2 CH 2; Z is a covalent bond, -CH 2 - or -CH 2 CH 2, provided that when Y is -CH 2 CH 2 -, Z is a valence bond; R 1 is selected from the group consisting of X and XXV; R3 is hydrogen, alkyl or halogen; R4 is hydrogen, alkoxy, alkyl, amino, halo or nitro; R5 is hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonyloxy, alkylthio -, alkynyl, amino, aminoalkyl, aminocarbonyl, aminocarbonylalkyl, aminosulfonyl, carboxyl, carboxyalkyl, cyano, cyanoalkyl, formylformyl, alkyl, halogenated alkoxy, halogenated alkyl, halogen, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, 5-tetrazolyl, -NR 6 S (O) 2 R 7, -C (NR 6) NR 7 R 8, -CH 2 C (NR 6) NR 7 R 8, -C (NOR 6) R 7, -C (NCN) R 6, -C (NNR 6 R 7) R 8, -S (O) 2 OR 6 or -S (O) 2 R 6; R6, R7 and R8 are each independently hydrogen or alkyl; and R 9 is hydrogen, alkoxycarbonyl, alkyl, amino, aminoalkyl, aminocarbonylalkyl, benzyloxycarbonyl, cyanoalkyl, dihydro-3-pyridinylcarbonyl, hydroxyl, , hydroxyalkyl or phenoxycarbonyl. SHE |