| abstract |
The invention relates to effervescent granules which exhibit variable rate effervescence and which are processed by an acidic agent, a hot melt extrusion process, a eutectic blend binder with an acidic agent, a pharmacologically active agent and optionally a plasticizer; and a mixture of an alkaline agent. The effervescent granulate is made by a thermal process in which said mixture is dry mixed and hot-melt extruded to form the effervescent granulate. The pharmacologically active agent may be, for example, a synthetic anti-diarrheal agent, a sedative, a diuretic, a serotonin agonist, a levorotatory isomer of thyroxine, a cholesterol lowering agent, an alpha-adrenergic blocking agent, an antiviral agent, a narcotic, an antidepressant. HE |