| abstract |
The present invention relates to metalloprotease inhibitor compounds of the general formula wherein R 1 is hydroxy or hydroxyamide; R2 is hydrogen, aliphatic, aromatic, heterocyclic hydrocarbon and halogen; n = 0-4; Monocyclic heterocyclic alkyl; Ecovalent bond, alkyl, carbonyl, carboxy, sulfonyl; X is hydrogen, aliphatic, aromatic, heterocyclic hydrocarbon; G is sulfur, oxygen, -N (R 5) -, -C (R 5) = C (R 5 ') -, -N = C (R 5) - and azo; Z is cycloalkyl and heterocycloalkyl and its optical isomers, diastereomers, or enantiomers, or their pharmaceutically acceptable salts, or their biohydrolyzable amides, esters, or imides, and pharmaceutical compositions and preparations thereof. SHE |