http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0300255-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c2c533156e157c6f401c7f6b8e1168b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-26 |
| filingDate | 2003-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_101be59984c0fca5b2c398791eca16a0 |
| publicationDate | 2004-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0300255-A2 |
| titleOfInvention | Process for the preparation of 2-phenyl-4-methyl-1-tosylpiperazine |
| abstract | The present invention relates to a novel process for the preparation of 2-phenyl-4-methyl-1-tosylpiperazine by the step of transferring (2-chloroethyl) - (2-chloro-2-phenylethyl) methylamine to a tosylamide catalyst and reacting in the presence of an acid scavenger with water and water. miscible organic solvent mixture. According to a preferred embodiment of the process, the styryloxide is reacted with 2- (methylamino) ethanol and then reacted directly with tosylamide following chlorination with thionyl chloride. The desired product is obtained by selective crystallization from the isomer mixture. The 2-phenyl-4-methyl-1-tosyl-piperazine produced by the method of the invention is an important intermediate in the preparation of mirtazepine, an antidepressant drug. HE |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102649779-A |
| priorityDate | 2003-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.