| abstract |
The present invention relates to metalloprotease inhibitor compounds of the general formula wherein R1 is hydroxy and hydroxylamide; R 2 is hydrogen, aliphatic, aromatic, heterocyclic hydrocarbon and halogen; R3 is an aliphatic, aromatic, heterocyclic hydrocarbon group; n = an integer from 0 to 4; Monocyclic Heterocycloalkyl; E is a covalent bond, alkyl, carbonyl, carboxy, sulfonyl; X is hydrogen, aliphatic, aromatic, heterocyclic hydrocarbon; G is S, O, -N (R 5) -, -C (R 5) = C (R 5 ') -, -N = C (R 5) - and azo; G 'is S, O, -N (R 6) -, -C (R 6) = C (R 6') -, -N = C (R 6) - and the same; M is -CH = and -N; Z is cycloalkyl and heterocyclic alkyl or their optical isomers, diastereomers, enantiomers, their pharmaceutically acceptable salts or their biohydrolyzable amides, esters or imides, pharmaceutical compositions containing them and their preparation. SHE |