http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0204395-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7e02134f8e73be58f71c75e4b0c4a3b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2001-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_809916ffc82ecdc7851b0da36024f1d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11ee08e2f07c392f87d70ca672121962 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0109f619e23bc16b6017c6c678af6871 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fb929ddf71d0812023e1587431df45a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0190d2016918774f525c133f095f048f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5310b7fd3dfe8b227022142cb17dc50a |
| publicationDate | 2003-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0204395-A2 |
| titleOfInvention | A new method for producing latanoprost |
| abstract | The present invention relates to a process for the preparation of latanoprost of formula (1) which comprises converting a compound of formula (5) to a compound of formula (7) which is hydrogenated in the presence of a catalyst to give a compound of formula (9) at -50 ° C to + 50 ° C. Diisobutylaluminum hydride is reduced at a temperature of C and the resulting reaction mixture is hydrolyzed under basic conditions to give a compound of formula (11) which is converted to latanoprost of formula (1) wherein one of R1 and R2 is arylcarbonyl and the other is arylcarbonyl. arylcarbonyl, acyl, trialkylsilyl, dialkylarylsilyl, 1-alkoxyalkyl, unsubstituted or alkyl-substituted tetrahydro-2H-pyran-2-yl or tetrahydrofuran-2-yl and R3 is hydrogen when R1 is acyl and R3 is R1 the same when trialkylsilyl, dialkylarylsilyl, 1-alkoxyalkyl, unsubstituted or alkyl-substituted tetrahydro-2H-pyran-2-yl or tetrahydrofuran-2-yl; R4 is hydrogen when R2 is acyl, R4 and is the same as R2, amicortrialkylsilyl, dialkylarylsilyl, 1-alkoxyalkyl, unsubstituted or alkyl-substituted tetrahydro-2H-pyran-2-yl or tetrahydrofuran-2-yl . SHE |
| priorityDate | 2000-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 121.