| abstract |
The present invention relates to the use of a selective estrogen receptor modulator, in particular a compound of formula (I) and an estrogen / orrogen mixed estrogen to reduce the incidence of hot flushes and menopausal symptoms by reducing the risk of hypertension, , for the treatment and / or prevention of insulin resistance, diabetes, muscle mass loss, obesity, irregular menstruation, Alzheimer's disease or vaginal dryness. The addition of bisphosphonates or sex steroid precursors is also described in some of the above diseases. The invention also relates to pharmaceutical compositions containing active ingredients. In the general formula (I), R1 and R2 are independently hydrogen or hydroxy; n is 1 or 2. Oh |