| abstract |
A controlled release formulation comprising an opioid agonist, an opioid antagonist, and a controlled release substance, provides an analgesic or sub-analgesic opioid agonist during the dosing interval with an amount of opioid antagonist that is effective in attenuating the opioid agonist side effects. The preparation provides analgesic effect for sick people for up to 8 hours. In other embodiments, the antagonist dose administered during the dosing interval increases the analgesic effect of the opioid agonist. The invention extends to the preparation of the composition. HE |