| abstract |
The present invention provides compounds of formula I wherein: R1 and R2 are halogen; alkyl, alkoxy. nitro, trifluoromethyl, cyano or optionally substituted amino or thiol; wherein the carbonene atom may be single or double oxidized; R3 is hydrogen or R1 is as defined above; R4 is hydrogen or halogen; alkyl, cycloalkylcycloalkylalkyl or Rc-X-alkyl wherein Rc is hydrogen or alkyl and X is -O-, -S-, -SO- or -SO2-; R5 is alkyl, alkynyl, alkenyl, cycloalkylalkyl or alkyl-X- (C0-C3-alkyl), wherein X is -O-, -S-, -SO- or -SO2-; R6 is substituted phenyl or R6-CHR7R8 wherein: R7 is acycloalkyl or substituted phenyl; or optionally substituted pyridyl; - R8 is alkyl, cycloalkyl, cycloalkylalkyl or alkyl-X-alkyl, wherein X is -O-, -S-, -SO- or -SO2-; or cycloalkylalkyl-X-alkyl, wherein X is -O-, -S-, -SO- or -SO2-. The compounds are useful in the prevention or treatment of CRF-dependent disorders. The invention also relates to the preparation of the compounds and to pharmaceutical compositions containing them. SHE |