| abstract |
SUMMARY OF THE INVENTION The present invention relates to compounds of formula (I) as well as to their pharmaceutically acceptable salts, prodrugs, or therapeutically effective metabolites or prodrugs of their pharmaceutically acceptable salts. In formula (I), R1 is a substituted or unsubstituted aryl, heteroaryl, carbocyclic or heterocyclic group; or a group of formula (a) wherein R 4 is hydrogen or lower alkyl, and X is a substituted or unsubstituted alkyl, aryl, heteroaryl, carbocyclic or heterocyclic group; and R 2 is a substituted or unsubstituted aryl, heteroaryl, carbocyclic or heterocyclic group; or a group of formula (a) wherein R4 is hydrogen or lower alkyl, and X is substituted or unsubstituted alkyl, aryl, heteroaryl, carbocyclic or heterocyclic. The active indazole compounds of the present invention modify and / or inhibit cell proliferation, such as inhibition of protein kinase activity. by. The compounds and their active ingredients, as active ingredients, are therefore useful in the treatment of kinase-dependent diseases such as cancer and other cell proliferative diseases and pathological conditions. In addition, the agents of the invention also inhibit angiogenesis (e.g. angiogenesis), such as exacerbation of diabetic retinopathy. HE |