abstract |
The present invention relates to the use of substituted 4-amino-1-phenylbutan-2-ol derivatives of the formula (I) in the form of their racemates, enantiomers, diastereomers or salts of appropriate bases or salts of appropriate physiologically acceptable acids as a Nociceptin / Orphanin the preparation. In the formula (I), A is aryl or heteroaryl, R 1 and R 2 are independently C 1-6 alkyl, preferably C 1-3 alkyl, or R 1 and R 2 together form a (CH 2) 2-6 ring, where R3 and R4 are independently C1-C6 alkyl, preferably C1-C3 alkyl, aryl or aryl linked via a C1-C3 alkylene group, or R3 and R4 together are (CH2) 3-6 or CH2CH2OCH2CH2 , R5, R6 and R7 are independently hydrogen, fluorine, chlorine, bromine, iodine, or CF3, OR8, SO2CH3, SO2CF3, phenyl, CN, NO2, or C1-C6 alkyl, R8 is hydrogen, 1 -C 6 -alkyl, preferably C 1-3 -alkyl, aryl, heteroaryl, or aryl or heteroaryl attached via a C 1-3 -alkylene group. SHE |