http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0203369-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2722fd2ecc8e1e55fbc3bb2ba9fc53fc |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-08 |
| filingDate | 2000-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd781da40ee03c454b84ccd55872e5d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97679126d6a8e4dd27dfc8fbb974c130 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20d9d0f9c6fb85ad41eeff25a42efcce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bffeacadd077e0c0e5e4ce22e089d742 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3270db009af455f642bf8ff8f99ee976 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f79de10004ede3602ca7304b4f86e84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b621e96fe4337a088baf59b2b5286d3 |
| publicationDate | 2003-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0203369-A2 |
| titleOfInvention | Polycycloalkylurines with adenosine receptor antagonist activity, process for their preparation and use |
| abstract | The invention is based on the discovery that the compounds of formula (1) are unexpectedly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be used to prevent and / or treat various diseases, including cardiovascular disorders, degenerative disorders of the central nervous system, respiratory disorders and a number of diseases for which diuretic therapy is indicated. One aspect of the invention is a compound of formula (1). The invention also relates to the preparation and use of the compounds. In formula (I), R1 and R2 are independently hydrogen, alkyl, alkenyl or alkynyl, which are also optionally substituted with aryl; R3 is optionally substituted bicyclic or tricyclic; R4 is hydrogen, alkyl or alkyl-CO2H or phenyl, wherein alkyl or phenyl may be substituted; R 5 is -CH 2 COOH, -CCCF 3 OH -CONHOH-SO 2 CF 3; -CONR4 -CONHSO2R4; X1 and X2 are independently O or S, Z is a single bond, O, - (CH2) 1-3 -O- (CH2) 1-2- or -CH = CH-CH2-, -CH = CH- , R6 is hydrogen, alkyl, acyl, alkylsulfonyl. HE |
| priorityDate | 1999-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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