| abstract |
The present invention relates to compounds of formula I wherein Ar 1 is optionally substituted aryl or heteroaryl; n is 0 or 1; T, U, V and W are independently N, or an optionally substituted methine group, and at least two of these substituents are methine; X is methyl or nitrogen; Y is optionally substituted imino or oxygen. The compounds of the invention exhibit antagonistic activity against neuropeptide Y (NPY in short) and are useful as agents for the treatment of various diseases associated with the NPY receptor. Pathologic conditions that can be considered in terms of treatment include, for example, cardiovascular diseases such as hypertension, kidney disorders, heart disease, vasospasm, arteriosclerosis; and central nervous system disorders such as bulimia, nervousness, depression, anxiety, seizures, epilepsy, weakness, pain, alcoholism, drug withdrawal; as well as metabolic disorders such as obesity, diabetes, hormonal disorders, abnormally high blood cholesterol, hyperlipidemia; impairment and impairment of sexual and reproductive function; gastrointestinal disorders; diseases of the respiratory system; inflammation and glaucoma. The present invention relates to the preparation of the compounds and to pharmaceutical compositions containing them. SHE |