| abstract |
The present invention relates to novel benzimidazoles of the general formula: wherein Anaftalin or at least partially aromatic and optionally more R3 and / or heteroaromatic substituted with R4; R1 is hydrogen, chloro, fluoro, bromo, iodo, alkyl, \ t hydroxy, nitro, trifluoromethyl, cyano, -NR 11 R 12, -NH-CO-R 13 or -O-alkyl in which R 11 and R 12 are hydrogen or alkyl, and R 13 is alkyl, phenylalkyl or phenyl; R2 is hydrogen or alkyl; R 3hydrogen, chlorine, bromine, iodine, fluorine, trifluoromethyl, trifluoromethoxy, nitro, amino, -CO-R 8, -CO 2 -R 8, -SO 2 -R 8, hydroxy, -O-alkyl - phenylalkyl-O-, an optionally substituted chain, phenyl or pyridyl; R4 is hydrogen or - (D) p- (E) s- (CH2) q-B and is prepared for use in the manufacture of pharmaceutical compositions for their use as inhibitors of poly (ADP-ribose) polymerase or PARP (EC 2.4.2.30). HE |