http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0202907-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D279-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D279-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-10 |
| filingDate | 2002-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f29f3e7f7fdcbe0981fa77b19c4447e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6551c507dfd5699b652b7af56a029405 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8add88b30178126cad24849c8345997f |
| publicationDate | 2003-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0202907-A2 |
| titleOfInvention | Process for the preparation of 2- (4-alkyl-1-piperazinyl) benzaldehyde and benzylidenyl compounds \ t |
| abstract | An improved process for the preparation of compounds of formulas I and II, and pharmaceutically acceptable salts thereof, wherein R1 is C1-C6 alkyl and R2 is - (CH2) mB wherein m is 0, 1, 2 or 3, and B is optionally substituted with one or more groups independently selected from chlorine, fluorine, bromine, iodine, (C 1 -C 6) -alkyl, (C 1 -C 6) -alkoxy, (C 1 -C 6) -alkoxy, (C 1 -C 6) -alkyl, phenyl or naphthyl substituted with trifluoromethyl, trifluoromethoxy and / or cyano. The preparation of compounds of formula (I) according to the invention involves reacting a compound of formula (III) with a compound of formula (IV) in the presence of water and a metal carbonate, and optionally salifying the resulting compound; and a process for the preparation of compounds of formula (II) by: (a) reacting a compound of formula (III) with a compound of formula (IV) in the presence of water and a metal carbonate; b) reacting the compound of formula I obtained in step a) with monohydrochloride or gaseous hydrochloric acid dissolved in an aqueous alkanol; and c) the hydrochloride salt of compound I in step b) in the presence of a base in a suitable solvent; R2 is as hereinbefore defined. HE |
| priorityDate | 2001-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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