| abstract |
kPage = N; BrkToNext = N;> (57) The present invention relates to the use of N-substituted indole-3-glyoxylamides of formula (1) in the treatment of tumors, wherein R is hydrogen, C1-6 optionally mono- or polysubstituted by a phenyl ring. alkyl, where the phenyl ring may be substituted, and benzyloxycarbonyl, tert-butoxycarbonyl or acetyl; R1 is an optionally substituted phenyl ring, a substituted pyridine residue or its N-oxide, an optionally substituted pyrimidinyl, quinolyl or quinolylmethyl group, or when R is H, Z, BOC, acetyl or benzyl, R1 may be an amino acid residue, and R and R1 together with the adjacent nitrogen atom form a piperazinyl or homopiperazinyl group, R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl or aroyl group; R3 and R4, identically or differently, are hydrogen, halogen, C1-6-alkyl, alkanoyl, alkoxy, C3-7-cycloalkyl, benzyloxy, amino, alkylamino, nitro, alkoxycarbonyl amino; Z is oxygen or sulfur. The invention also relates to pharmaceutical compositions containing the compounds of formula (1). SHE |