| abstract |
The present invention relates to compounds of formula I, wherein R1 is typically a one or two-membered, optionally substituted aromatic ring or phenyl group directly attached to the nitrogen by either a -CH2- or a group, Z is a pyrrolidine or thiazole or oxazole ring, optionally it may also carry a substituent; up to 2 or 3 - and their pharmaceutical compositions, intermediates and their synthesis. The compounds of formula (I) are inhibitors of the enzyme DPP-IV and, therefore, can be converted into active ingredients for the treatment of diabetes. |