| abstract |
The present invention relates to ethyl (2S) -2- (naphthalene-1-sulfonylamino) -3- (4- (2- (1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl) ethyl) formula (I). ) ethyl ethyl benzoylamino) propionate hemifumarate. The present invention relates to the preparation of an abase comprising 4- (2- (1,4,5,6-tetrahydropyrimidin-2-ylcarbamoyl) ethyl) benzoic acid or a derivative thereof and ethyl (2S) -3-amino- 2- (Naphthalene-1-sulfonylamino) -propionate is reacted. The compound of formula (I) is a valuable drug that can be used, for example, to treat or prevent diseases that can be affected by inhibition of the vitronectin receptor, in particular acne diseases, e.g. osteoporosis. The invention also relates to chemical intermediates of formula (XIII) and (XV) useful in the preparation of a compound of formula (I), wherein Y is a chlorine or bromine atom or a hydroxyl group. SHE |