abstract |
The invention relates to (a) compounds of general formula (I) in free form or in the form of a salt wherein X is oxygen, sulfur or NR5; R1 may be optionally substituted alkyl, alkenyl, cycloalkyl, benzocycloalkyl, cycloalkylalkyl or aralkyl, or when X is NR5, may also be a heterocyclic group or a group of formula II; R2, R3, R4, R6, R7 and R8 are hydrogen, halogen, alkyl, haloalkyl, alkoxy, carboxy, alkoxycarbonyl, carboxyalkyl, (alkoxycarbonyl) alkyl, - N (R 9) R 10, -SO 2 N (R 11) R 12, - (alkylene) -SO 2 N (R 11) R 12 or -CON (R 13) R 14, or when two of R 2, R 3 and R 4, or two of R 6, R 7 and R 8 are indicated. bonded to adjacent carbon atoms of the benzene ring, said two substituents, together with the carbon atoms to which they are attached, may form a carbocyclic group or a heterocyclic group containing two or three heteroatoms; R5, R9, R11, R13 and R14 are hydrogen or alkyl; R10 is hydrogen, alkyl or -COR15 wherein R15 is alkyl, haloalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, carboxyalkyl or (alkoxycarbonyl) alkyl; or R9 and R10 may be taken together with the nitrogen atom to form a heterocyclic group containing one or two heteroatoms; R12 is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, (alkoxycarbonyl) alkyl, or R11 and R12 can form a heterocyclic group containing one or two heteroatoms in the nitrogen atom, in particular for use as a medicament, and (b) a compound of formula (I) as defined above, in free form or as a salt thereof, for use in the preparation of a medicament for the treatment of conditions mediated by syk kinase. SHE |