| abstract |
The present invention relates to bicyclic heterocyclic compounds of the formula wherein R a is hydrogen or alkyl; Rb is optionally substituted phenyl, benzyl or 1-phenethyl; Rc and Rd are hydrogen, fluorine or chlorine, methoxy or methyl substituted by various groups; X is N or = C (CN) -; A and C are alkylene, substituted alkylene oxy, or substituted alkylene amino; B and D (alkoxycarbonyl) alkenylamino, (alkoxyphosphoryl) alkenylamino or various substituted ring amino groups which are physiologically acceptable salts thereof which inhibit signal transduction mediated by atirosin kinases and are therefore useful in the treatment of various diseases. compounds. SHE |