| abstract |
A process for the preparation of spiro-(cis-(4-(beta -hydroxyethyloxy)cyclohexane (3H)indol)-2'(1'H)-one derivatives (I) is new. Preparation of spiro-(cis-(4-(beta hydroxyethyloxy)cyclohexane-(3H)indol)-2'(1'H)-one derivatives of formula (I) comprises reduction of a dispiro((1,3-dioxolane)-2,4' cyclohexane-1',3-(3H)indol)-2(1H)-one derivative of formula (II) with either: (a) sodium cyanoborohydride in the presence of a Lewis acid, or (b) sodium borohydride in the presence of a strong acid. [Image] R 1>, R 2>H, 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio, 1-4C polyfluoroalkyl, 1-4C polyfluoroalkoxy, 3-7C cycloalkyloxy, 3-7C cycloalkylthio, phenoxy, benzyloxy or NO 2. |