| abstract |
The present invention relates to novel 1- (arylsulfonyl, arylcarbonyl or arylthiocarbonyl) pyridazine derivatives of the formula (I) and their preparation. In the formula I, L is carbonyl, thiocarbonyl or sulfonyl; R 1 and R 2 independently of one another are hydrogen or halogen or alkyl, haloalkyl, nitro, cyano, carboxylalkoxycarbonyl, provided that when L is a sulfonyl group, then R 1 and R 2 are not hydrogen; R3 is independently selected from two or three hydrogen or halogen atoms or alkyl, haloalkyl, nitro, carboxyl or alkoxycarbonyl in the alkoxy moiety; and X is a divalent group of the general formula - (CH 2) n - or -Y- (CH 2) n-1, wherein N is 1, 2 or 3 and Y is oxygen or sulfur. The compounds of formula I have non-steroidal heterocyclic compounds that have selective progestin and / or antiprogestin activity and thus have an invitatory action on progestin receptors in the uterus, breast or bone, and are useful, for example, as a contraceptive or in the treatment of menopause, osteoporosis. HE |