| abstract |
The present invention relates to compounds of formula I, their enantiomers, diastereoisomers and salts thereof with a pharmaceutically acceptable acid or base wherein X is a bond, alkylene, CO, S (O) n, * -S (O) n-A1-, * -CO-A1-, -A1-S (O) n-A'1- and -A1-CO-A'1-, wherein A1 and A'1 are alkylene and n is 0, 1 or 2 and * represents the point of attachment of the groups to cycloheptene; Y is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each of which is unsubstituted or substituted; R1, R2, R3 and R4 are independently hydrogen or aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each of which is unsubstituted or substituted, or is taken together to form pairs of R1, R2, R3 and R4, either fused or fused to a fused benzo ring or fused forms a ring; T is -CH (R 5), -N (R 5) - or * -N (R 5) CO - wherein R 5 is hydrogen or alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl, each of which is unsubstituted or substituted, and * represents the point of attachment of these groups to acycloheptene; V is hydrogen or unsubstituted or substituted aryl or heteroaryl; A2 is a group of the general formula [C (R6) (R'6)] wherein p is 0, 1, 2, 3 or 4, R6 and R'6 are the same or different and are hydrogen or alkyl, alkenyl, alkynyl, optionally substituted aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl or heterocycloalkylalkyl. The present invention also relates to pharmaceutical compositions containing the above compounds as active ingredients, and to their use in the manufacture of a medicament for the treatment of cancerous disorders, coronary artery bypass grafting or re-occlusion after vascular surgery or type I neurofibromatosis. The invention also relates to a process for the preparation of the above compounds. HE |