| abstract |
The present invention comprises compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein X1, X2, R2, R8, R9, R10 and R11 are as defined below. The compounds of formula (I) nos are useful as antimicrobial and antiprotozoal agents and are thus useful in the treatment of various bacterial and protozoal infections. Methods of treating bacterial and protozoal infections by the administration of compounds of formula I-nos: X1 is O, -CR4R5- or -NR4-ltal nos; X2 is = O or = NOR1tal nos; R1 is R 2 is - (CR 4 R 5) n (4-10 membered heterocycle) - or - (CR 4 R 5) n (6-10 membered aryl); R 4 and R 5 are hydrogen or C 1-6 alkyl; R8 is hydrogen, -C (O) (C1-C6 alkyl), benzyl, benzyloxycarbonyl or (C1-C6 alkyl) 3-silyl, R9 is (C1-C6) alkyl, R10 is hydrogen or 1-1 C 0 alkyl |