| abstract |
The present invention relates to compounds of formula (I) and salts thereof wherein A is a radical free radical (X), X is a substituent, especially a bis substituent, C 1 -C 6 straight or branched alkyl; Y is an optionally substituted alkyl, alkenyl or alkynyl group containing up to 10 carbon atoms (most basic substituents) having up to 10 carbon atoms, or an alkylene group containing sulfur or nitrogen; R10 is hydrogen, OH, CN, NO2 or sulfide; or an alkyl or alkoxy group. The active substances present in the invention contain genes for the NO-level z enzyme, either to react with reactive oxygen units (ROS) or to inhibit lipid peroxide cation or a combination of these six. compounds for example in the treatment of cardiovascular diseases (cardiac or cerebral infarction), thromboses, central and peripheral cerebrovascular diseases, e.g. in the treatment of neurodegenerative diseases (Alzheimer's disease, Parkinson's disease); can play a role in the treatment of musculoskeletal disorders, cell proliferation and inflammatory diseases, in the resolution of organ transplantation complications and, more generally, in the treatment of pathological conditions that are characterized by excessive production of NO and / or reactive oxygen species / The present invention also encompasses pharmaceutical compositions containing compounds |