http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-0104942-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dac022280ec96f54c694eb427655932 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-60 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-429 |
| filingDate | 1999-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84444ce61c35bbdf05774c97e6c1ee6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf932f7db0a3f58a012d63842eafc236 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44e55ad3a724c9062e4b59f9081bfd40 |
| publicationDate | 2002-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-0104942-A2 |
| titleOfInvention | Polycyclic thiazolidin-2-ylidene amines, a process for the preparation of compounds and their use as medicaments |
| abstract | The present invention relates to polycyclic thiazolidin-2-ylidene amines and their physiologically acceptable salts and physiologically reactive derivatives thereof. The substituents of the present polycyclic thiazolidin-2-ylidene amines (I) have the meanings given below. The invention also encompasses processes for the preparation of physiologically acceptable salts and their preparation, and pharmaceutical compositions containing the compounds. Y is a bond, -CH 2 - or -CH 2 -CH 2 -; X is -CH 2, CH (CH 3), CH (C 2 H 5), CH (C 3 H 7); R 1 is cyano. , carboxyl, COO (C 1-6 alkyl), carboxamido, CONH (C 1-6 alkyl), CON (C 1-6 alkyl) 2, C 2-6 alkyl, C 2-6 alkenyl -, C 2-6 alkynyl, O-CH 2 -CF 3, O-CH 2 -CF 2 -CF 3 or O- (C 4 -C 6) alkyl, where one or more hydrogen atoms in the alkyl group may be replaced by fluorine, or a single hydrogen atom may be hydroxyl- , OC (O) CH 3, O-CH 2 -phenyl, amine or N (COOCH 2 Ph) 2, S- (C 1-6 alkyl) -, S- (CH 2) n -phenyl, SO 2 - (1-6). C 1 -C 4 alkyl, SO 2 - (CH 2) n -phenyl, SO 2 - (C 1 -C 6 alkyl), SO 2 - (CH 2) n -phenyl, where n is 0 to 6 k "z" integer m; R1 'is hydrogen, fluorine, chlorine, bromine or iodine, or methylmethyl, trifluoromethyl, O- (C1-C3 alkyl), nitro, SO2-NH2, SO2NH (C1-C6) alkyl), SO 2 N - (C 1 -C 6 alkyl) 2 - or R 1, R 2 is hydrogen, (C 1 -C 6) alkyl, (C 3 -C 6) cycloalkyl, (CH 2) n -phenyl, (CH 2) n -thienyl- , (CH2) n-pyridyl, (CH2) n-furyl, C (O) - (CH2) n-phenyl, C (O) - (CH2) n-thienyl, C (O) - (CH2) ) n-pyridyl, C (O) - (CH 2) n -furyl, wherein n is 0-5 k "z" and wherein phenyl, thienyl, pyridyl or furyl is not more than two chloro; may be substituted by fluorine, cyano, trifluoromethyl, C 1-3 alkyl, hydroxy, O- (C 1-6 alkyl), C (O) - (C 1-6 alkyl) -, C (O) - (C 3 -C 6) cycloalkyl; R3 is hydrogen, C1-C6 alkyl, fluoro, cyano or azido, O- (C1-C6 alkyl), CH2-COO (C1-C6 alkyl), CH2-COO (C3-C8 cycloalkyl). -, CH2-COOH, CH2-CONH2, CH2-CONHCH3, CH2-CON (CH3) 2, (CH2) n-phenyl, (CH2) n-thienyl, (CH2) n-pyridyl, (CH2) n -furyl, where n is 0-5 k "z" and wherein the phenyl, thienyl, pyridyl or furyl group has up to two chlorine, fluorine, cyano, trifluoromethyl, C 1-3 alkyl, hydroxy, O- (C 1 -C 6 alkyl) optionally substituted, C 2 -C 6 alkynyl, C 2 -C 6 alkenyl, C (O) OCH 3, C (O) OCH 2 CH 3, C (O) OH, C ( O) NH 2, C (O) NHCH 3, C (O) N (CH 3) 2 or OC (O) CH 3; R 4 is C 1-6 alkyl, C 3-6 cycloalkyl, (CH 2) n -phenyl, (CH 2) n -thienyl; (CH2) n-pyridyl, (CH2) n-furyl, where n is from 0 to 5 k "z" |
| priorityDate | 1998-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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