| abstract |
The present invention relates to novel analogues of PACAP (pituitary adenyl t cyclic activating polypeptide). The compounds of the present invention are useful in the treatment of "a variety of pathological conditions and disorders such as cerebrovascular rischemia, male impotence, motor neuron disease, neuropathy, pain, depression, anxiety disorders, brain trauma, memory impairment, dementia, impaired ability, migraine, neurodegenerative diseases, ischemic heart disease, myocardial infarction, fibrosis, restenosis, diabetes mellitus, muscle disorders, gastric ulcer, stroke, atherosclerosis, hypertension, septic shock, thrombosis, retinopathy, or cardiovascular disease application. The present invention includes pharmaceutical compositions containing as active ingredient a PACAP peptide analogue or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. SHE |