| abstract |
The present invention provides compounds of formula I, prodrugs, N-oxides, addition salts, quaternary amines or stereochemically isomeric forms thereof, wherein R 1 is hydrogen, alkyl, halo, formyl, carboxyl, alkyloxycarbonyl, alkylcarbonyl, N (R 3 R 4) C (= O) -, N (R 3 R 4) C (= O) N (R 5) -, substituted ethenyl or substituted alkyl; R 2 is hydrogen, alkyl, hydroxyalkyl, alkyloxyalkyl, N (R 3 R 4) C (= O) -, aryl or halogen; n is 1 or 2; -A-B- is -Y-CH = CH- (a-1); -CH = CH-Y- (a-2) or -CH = CH-CH = CH- (a-3); wherein each of the hydrogen atoms of (a-1) to (a-3) may independently be replaced by R 6 and each Y is independently a bivalent -O-, -S-, or -NR 7 - group, Z is a bivalent group of formula - (CH 2) p (b-1), -CH = CH- (b-2), -CH 2 -CHOH- (b-3), -CH 2 -O- (b-4), -CH 2 -C (= O) - (b-5) or -CH 2 -C (= NOH) - (b-6), with the proviso that (b-3), (b-4), (b-5) and The bivalent groups of formula (b-6) are attached to the imidazole ring nitrogen atom at their -CH 2 - group; p is 1, 2, 3 or 4; L is hydrogen, alkyl, alkenyl, alkylcarbonyl, alkyloxycarbonyl, alkyl substituted with one or more substituents, or L is -Alk-Y-Het1 (c-1), -Alk-NH-CO-Het2 (c-2). ) or -Alk-Het3 (c-3) n-ol The compounds of this invention are also used as pharmaceuticals, pharmaceutical compositions containing them, pharmaceutical compositions containing ( Compounds of general formula IIa), their N-oxides, addition salts, quaternary amines or stereochemically isomeric forms thereof, as well as their compounds of general formula I and II and their derivatives. |