| abstract |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R 1 -R 5 are independently hydrogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halogen. , cyano, nitro, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8, -NR6N (R7R8), -N (R7R8) or WY- (CH2) nZ1tal nos. or R2 and R3 or R3 and R4 together are a 3-7 membered heterocycloalkyl or a 3-7 membered heteroaryl; R6 and R7 are each independently hydrogen, alkyl, perhaloalkyl, or aryl; R8 is hydrogen, alkyl, perhaloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or R7 and R8 together may form a 3-7 membered heterocycloalkyl group; A is heteroaryl; W is O, -NR 6 l-nos, or is absent; Y is - (CO) - or - (CO2) - or absent; Z is C1-C4 alkyl, cyano, -CO2R6, -COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N (R7R8), -N (R7R8) a group of the general formula or phenyl; G is aryl or heteroaryl; X is a bond, -NH-, alkyl, alkenyl, alkoxy, alkylthio, (C 1 -C 6) -alkylamino, or (CH) -; (J) is alkyl, cycloalkyl, and n is from 1 to 6. The compounds are genes and / or cure herpes viruses, such as hum n cytomegaloviruses, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, hum nherpesvirus-6 and -7. and Kaposi's herpesvirus. |