| abstract |
SUMMARY OF THE INVENTION The present invention relates to a compound of formula I wherein W is oxygen or sulfur; X is NR8; Y is CR 9 R 10 - (CH 2) n -, wherein R 9 and R 10 are independently hydrogen or lower alkyl; n is an integer from 0 to 3; or Y is SO 2; R1 is aryl; R2 is a one or two ring heteroaryl containing one or more nitrogen atoms, provided that R2 is not 2-phthalimidyl and when Y is SO2, R2 is not 2,1,3-benzothiadiazol-4-yl ; R3, R4 and R5 are independently hydrogen or a substituent other than hydrogen; and R7 and R8 are each independently hydrogen, lower alkyl, an N-oxide, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing these. The compounds of formula (I) inhibit the VEGF receptor tyrosine kinase activity and can thus be used in the treatment of neoplastic diseases such as cancer and retinopathy and macular degeneration associated with aging. SHE |