| abstract |
The present invention relates to novel 17-halogenated 19-nor steroids having the general formula (I) wherein X is halogen, Y is a bond, oxygen, sulfur, NH, SO or SO 2, Z is hydrogen or halogen, n, R 1, R 2 , R3 and R4 are different organic groups. The invention also relates to the preparation of compounds and their intermediates, to the use of the compounds as medicaments, and to pharmaceutical compositions containing the compounds, which are useful for hormone replacement during menopause. SHE |