| abstract |
The present invention relates to compounds of formula (I) and salts thereof - wherein R1 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkoxyamino, or optionally substituted hydroxyamino; and R2 is optionally substituted alkyl or optionally substituted phenyl; and when R1 is unsubstituted alkyl, then R2 is substituted alkyl or substituted phenyl. The invention also relates to the preparation of the above compounds, their use in the preparation of gonadotropin releasing hormone antagonizing pharmaceutical compositions, and to pharmaceutical compositions containing the above compounds. The compounds of the present invention are useful in sex hormone dependent diseases such as sex hormone dependent cancers (e.g., prostate cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, . prevention and treatment. HE |