| abstract |
The present invention relates to novel tricyclic sulfonamide derivatives of formula I wherein n is 0 or an integer of 1 to 2, X is -O-, -NR 2 -, -CH 2 - or = CO, R is hydrogen or aliphatic. or an optionally substituted aromatic hydrocarbon radical, D is 0 or an integer of 1 to 3, L is 0 or an integer of 1 to 3, R1 is a hydrogen or a natural or unnatural amino acid residue, Y is OR3, or NH-OR4, and their corresponding isomers and pharmaceutically acceptable salts thereof; The compounds of the present invention are matrix metalloproteinase inhibitors and are useful in the treatment of a variety of diseases. SHE |