| abstract |
The present invention relates to triisubstituted imidazole compounds of formula (I) nose and derivatives thereof, wherein R1 is optionally substituted heteroaryl; R4 is optionally substituted aryl or heteroaryl; and R2 is optionally substituted cycloalkyl or cycloalkylalkyl. The process also includes processes for the preparation of the trisubstituted ltimidazoles according to the invention. The compounds of the present invention are useful in the treatment of cytokine-mediated diseases. Pharmaceutical compositions for use in such a field are also essential ingredients. |