| abstract |
The present invention provides novel 3,5-disubstituted 1,2,4-thiadiazole compounds of formula II wherein A is an amino acid residue or a peptide having 2 to 3 amino acid residues; W is -N (R 1) 2 or -OR 1, with the proviso that the group -A-W may not be of formula (2.1), (2.2), (2.3) and (2.4); Y represents the organic salts of an organic group. The compounds of the invention inhibit cysteine activity dependent enzymes and cysteine proteases. They are therefore suitable for treating, for example, acne, colds and inflammatory joint diseases. SHE |