| abstract |
The present invention provides compounds of formula (I) wherein m is 1-6, R is hydrogen, COR1, amino, NH-Pg or NHCOR2, R1 is hydroxy, C1-6 alkoxy or NR3R4, Pg is an amino protecting group, R2 is a C1-6 alkyl group, a substituted C1-4 alkyl group, an aryl group, a substituted aryl group, a (CH2) n-heterocyclic group or a substituted (CH2) n-heterocyclic group, R3, in any case, is independently hydrogen or 1-6 carbon; alkyl, R4 is C1-6 alkyl, norbornan-2-yl, aryl, substituted aryl, CH2 (CH (CH3) -phenyl, (CH2) n-heterocyclic or substituted (CH2) n-heterocyclic; n is 0, 1 or 2 and pharmaceutically acceptable salts or solvates of these compounds. pharmaceutical compositions containing these compounds and the use of these compounds in the manufacture of anticancer chemotherapeutic drugs. SHE |