| abstract |
The present invention relates to amides of the general formula wherein R1 is alkyl, phenyl, naphthyl, quinolyl, pyridyl, pyrimidyl, pyridazyl, quinazolyl, and quinoxalyl, wherein the rings may have two R4 substituents and R2 - (CH2) -. m-R8 wherein R8 is phenyl, cyclohexyl or indolyl and m is an integer from 1 to 6 and X is methylene, ethylene, ethenylene, ethynylene, -CONH, -SO2NH- and R 1 and X together and R 3 are hydrogen and -CONR 6 R 7, R 4 is hydrogen, alkyl and alkoxy, R 5 is hydrogen, alkyl and alkoxy, R 6 is hydrogen, alkyl, R 7 is hydrogen, alkyl, and n = 0, 1 or 2. and their tautomeric and isomeric forms, their possible enantiomers and diastereomeric forms, and their physiologically acceptable salts, which are inhibitors of various enzymes, in particular cysteine proteases such as calpain and isoenzymes and cathepsin. HE |