| abstract |
The present invention relates to compounds of formula (I) wherein: W is -OH or -NHOH; X is a) an unsubstituted or substituted heterocyclic group and a 10 to 15 membered tricyclic ring system containing at least one heteroatom in a ring containing at least one carbon atom in which each ring of the heteroatom-containing heterocyclic group may contain 1, 2 or 3 heteroatoms; provided that when X is a nitrogen-containing heterocyclic group, the heterocyclic group is attached to the (CH2) m group via a ring nitrogen atom, with the proviso that the nitrogen and sulfur heteroatoms of the heterocyclic group may be oxidized; b) -NR1SO2R2 where R1 is hydrogen, optionally substituted alkyl, heterocyclylalkyl, aralkyl or heteroarylalkyl, and R2 is hydrogen, optionally substituted alkyl, heterocyclylalkyl, aralkyl, heteroarylalkyl, aryl or heteroaryl; c) heterocyclylalkylthio; -CONR2R3, wherein R2 and R3 together with the nitrogen atom to which they are attached form a 5-7 membered ring which may optionally contain another heteroatom; Y is carbon, nitrogen, oxygen or sulfur, with the proviso that when Y is carbon, n = 2; Z is optionally substituted alkyl; aryl; optionally substituted alkoxy; aryloxy; aralkyloxycarbonyl aryl; aralkyloxycarbonyl heteroaryl; heteroaryl, heterocyclyl, heteroaryloxy, -CONR'2R'3, -NR'1COR'2, -NR'1CONR'2R'3; -OCONR'2R'3, -NR'1COOR4, or -SO2R'2, wherein R'1 is hydrogen, optionally substituted alkyl, heterocyclylalkyl, aralkyl or heteroarylalkyl and R'2 and R'3 are each independently hydrogen, optionally substituted alkyl, heterocyclylalkyl, aralkyl, heteroarylalkyl, aryl or heteroaryl; or R'2 and R'3, together with the nitrogen atom to which they are attached, are a 5-7 membered ring optionally containing another heteroatom; R4 is optionally substituted alkyl, heterocyclylalkyl, aralkyl, aryl or heteroaryl; m is an integer from 1 to 6; and n is an integer of 1 to 2; or a pharmaceutically acceptable salt thereof. The compounds of formula (I) of the present invention are matrix-degrading metalloproteinase inhibitors. HE |